Version 5.4
| Bos taurus Protein: NHP2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||
| InnateDB Protein | IDBP-698018.2 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | NHP2 | ||||||||||
| Protein Name | H/ACA ribonucleoprotein complex subunit 2 | ||||||||||
| Synonyms | NOLA2; | ||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Protein | ENSBTAP00000008363 | ||||||||||
| InnateDB Gene | IDBG-645317 (NHP2) | ||||||||||
| Protein Structure |
|
||||||||||
| UniProt Annotation | |||||||||||
| Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Nucleus, nucleolus {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Note=Also localized to Cajal bodies (coiled bodies). {ECO:0000250}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
|
||||||||||
| Gene Ontology | |||||||||||
Molecular Function |
|
||||||||||
| Biological Process |
|
||||||||||
| Cellular Component |
|
||||||||||
| Protein Structure and Domains | |||||||||||
| PDB ID | |||||||||||
| InterPro |
IPR002415
H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45 IPR018492 Ribosomal protein L7Ae/L8/Nhp2 family IPR029064 50S ribosomal protein L30e-like |
||||||||||
| PFAM |
PF01248
|
||||||||||
| PRINTS |
PR00883
PR00881 |
||||||||||
| PIRSF | |||||||||||
| SMART | |||||||||||
| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q5E950 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 520891 | ||||||||||
| UniGene | |||||||||||
| RefSeq | NP_001015626 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | BC103161 BT021070 | ||||||||||
| GenPept | AAI03162 AAX09087 | ||||||||||