InnateDB Protein
|
IDBP-698088.2
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
GNB2L1
|
Protein Name
|
Guanine nucleotide-binding protein subunit beta-2-like 1
|
Synonyms
|
RACK1;
|
Species
|
Bos taurus
|
Ensembl Protein
|
ENSBTAP00000026183
|
InnateDB Gene
|
IDBG-645383 (GNB2L1)
|
Protein Structure
|
|
Function |
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in aortic endothelial cells (EC) and the endothelium of tumor neovascularizations. Differential gene expression is displayed in the corpora lutea of the early, mid, and late stages of the ovarian cycle that are associated with progressive, active, and regressive stages of angiogenesis. {ECO:0000269PubMed:11099474}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 125 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
125 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0001934
|
positive regulation of protein phosphorylation
|
GO:0006417
|
regulation of translation
|
GO:0006915
|
apoptotic process
|
GO:0006919
|
activation of cysteine-type endopeptidase activity involved in apoptotic process
|
GO:0007049
|
cell cycle
|
GO:0007275
|
multicellular organismal development
|
GO:0007369
|
gastrulation
|
GO:0010629
|
negative regulation of gene expression
|
GO:0030178
|
negative regulation of Wnt signaling pathway
|
GO:0030308
|
negative regulation of cell growth
|
GO:0030335
|
positive regulation of cell migration
|
GO:0030822
|
positive regulation of cAMP catabolic process
|
GO:0032436
|
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
|
GO:0032464
|
positive regulation of protein homooligomerization
|
GO:0032880
|
regulation of protein localization
|
GO:0040008
|
regulation of growth
|
GO:0043065
|
positive regulation of apoptotic process
|
GO:0043524
|
negative regulation of neuron apoptotic process
|
GO:0043547
|
positive regulation of GTPase activity
|
GO:0048511
|
rhythmic process
|
GO:0050765
|
negative regulation of phagocytosis
|
GO:0051302
|
regulation of cell division
|
GO:0051343
|
positive regulation of cyclic-nucleotide phosphodiesterase activity
|
GO:0051726
|
regulation of cell cycle
|
GO:0051898
|
negative regulation of protein kinase B signaling
|
GO:0051901
|
positive regulation of mitochondrial depolarization
|
GO:0061099
|
negative regulation of protein tyrosine kinase activity
|
GO:1901299
|
negative regulation of hydrogen peroxide-mediated programmed cell death
|
GO:2000114
|
regulation of establishment of cell polarity
|
GO:2000543
|
positive regulation of gastrulation
|
GO:2001244
|
positive regulation of intrinsic apoptotic signaling pathway
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
IPR020472
G-protein beta WD-40 repeat
|
PFAM |
PF00400
|
PRINTS |
PR00320
|
PIRSF |
|
SMART |
SM00320
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P63243
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
327682
|
UniGene |
|
RefSeq |
XP_005199090
|
HUGO |
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
AJ132860
BC102286
|
GenPept |
AAI02287
CAB64792
|
|
|