InnateDB Protein
|
IDBP-698160.2
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ZWILCH
|
Protein Name
|
Protein zwilch homolog
|
Synonyms
|
|
Species
|
Bos taurus
|
Ensembl Protein
|
ENSBTAP00000006867
|
InnateDB Gene
|
IDBG-645460 (ZWILCH)
|
Protein Structure
|
|
Function |
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Chromosome, centromere, kinetochore {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
7 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR018630
RZZ complex, subunit zwilch
|
PFAM |
PF09817
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
A6QM04
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
534811
|
UniGene |
Bt.6676
|
RefSeq |
NP_001095649
|
HUGO |
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
BC148150
|
GenPept |
AAI48151
|
|
|