Version 5.4
Bos taurus Protein: FSTL3
Summary
InnateDB Protein IDBP-698205.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FSTL3
Protein Name Follistatin-related protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028801
InnateDB Gene IDBG-645504 (FSTL3)
Protein Structure
UniProt Annotation
Function The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0048185 activin binding
Biological Process
GO:0001503 ossification
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0022409 positive regulation of cell-cell adhesion
GO:0030514 negative regulation of BMP signaling pathway
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0045671 negative regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR002350 Kazal domain
IPR003645 Follistatin-like, N-terminal
IPR015369 Follistatin/Osteonectin EGF domain
IPR017878 TB domain
PFAM PF00050
PF07648
PF09289
PF00683
PRINTS
PIRSF
SMART SM00280
SM00274
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1LZB9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515367
UniGene Bt.5268
RefSeq NP_001069178
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116095
GenPept AAI16096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca