InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ECE1

Summary

InnateDB Protein

IDBP-698342.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ECE1

Protein Name

Endothelin-converting enzyme 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000037593

InnateDB Gene

IDBG-645619 (ECE1)

Protein Structure

UniProt Annotation

Function

Converts big endothelin-1 to endothelin-1.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0016787	hydrolase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0016485	protein processing
GO:0016486	peptide hormone processing

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR008753 Peptidase M13, N-terminal domain
IPR018497 Peptidase M13, C-terminal domain

PFAM

PF05649
PF01431

PRINTS

PR00786

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P42891

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281133

UniGene

Bt.4378

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC133320 Z35306

GenPept

AAI33321 CAA84547