InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AASDHPPT

Summary

InnateDB Protein

IDBP-69835.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AASDHPPT

Protein Name

aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000278618

InnateDB Gene

IDBG-69833 (AASDHPPT)

Protein Structure

UniProt Annotation

Function

Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. {ECO:0000269PubMed:11286508, ECO:0000269PubMed:12815048, ECO:0000269PubMed:18022563}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12815048}.

Disease Associations

Tissue Specificity

Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney. {ECO:0000269PubMed:11286508, ECO:0000269PubMed:12815048}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005515	protein binding
GO:0008897	holo-[acyl-carrier-protein] synthase activity

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009059	macromolecule biosynthetic process
GO:0015939	pantothenate metabolic process
GO:0044281	small molecule metabolic process