InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MUM1

Summary

InnateDB Protein

IDBP-698351.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MUM1

Protein Name

PWWP domain-containing protein MUM1

Synonyms

IRF4;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009840

InnateDB Gene

IDBG-645632 (MUM1)

Protein Structure

UniProt Annotation

Function

Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031491	nucleosome binding

Biological Process

GO:0006281	DNA repair
GO:0006325	chromatin organization
GO:0006974	cellular response to DNA damage stimulus

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08DK9

PhosphoSite

PhosphoSite-

TrEMBL

A7YSX5

UniProt Splice Variant

Entrez Gene

513471

UniGene

Bt.43056

RefSeq

NP_001069090

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC114659 BC123693

GenPept

AAI14660 AAI23694