Version 5.4
Bos taurus Protein: MUL1
Summary
InnateDB Protein IDBP-698392.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUL1
Protein Name mitochondrial E3 ubiquitin protein ligase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027782
InnateDB Gene IDBG-645664 (MUL1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019789 SUMO ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000266 mitochondrial fission
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007005 mitochondrion organization
GO:0007257 activation of JUN kinase activity
GO:0010637 negative regulation of mitochondrial fusion
GO:0030308 negative regulation of cell growth
GO:0033235 positive regulation of protein sumoylation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824 negative regulation of innate immune response
GO:0050689 negative regulation of defense response to virus by host
GO:0050821 protein stabilization
GO:0051646 mitochondrion localization
GO:0051898 negative regulation of protein kinase B signaling
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0071360 cellular response to exogenous dsRNA
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:0090141 positive regulation of mitochondrial fission
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0016020 membrane
GO:0031307 integral component of mitochondrial outer membrane
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR022170 Mitochondrial ubiquitin ligase activator of NFKB 1
PFAM PF13639
PF14634
PF12483
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BGD5
UniProt Splice Variant
Entrez Gene 508406
UniGene Bt.2006
RefSeq NP_001179111
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02006495 DAAA02006496
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca