InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NPRL2

Summary

InnateDB Protein

IDBP-698547.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPRL2

Protein Name

Nitrogen permease regulator 2-like protein

Synonyms

TUSC4;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025503

InnateDB Gene

IDBG-645795 (NPRL2)

Protein Structure

UniProt Annotation

Function

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. May act as a tumor suppressor (By similarity). As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0033673	negative regulation of kinase activity
GO:0043547	positive regulation of GTPase activity

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR009348 Nitrogen permease regulator 2

PFAM

PF06218

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9U9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

508487

UniGene

Bt.5235

RefSeq

NP_001015547

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105243 BT020810 BT020821

GenPept

AAI05244 AAX08827 AAX08838