Version 5.4
Bos taurus Protein: HYAL2
Summary
InnateDB Protein IDBP-698562.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HYAL2
Protein Name Hyaluronidase-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000612
InnateDB Gene IDBG-645811 (HYAL2)
Protein Structure
UniProt Annotation
Function Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0003824 catalytic activity
GO:0004415 hyalurononglucosaminidase activity
GO:0005515 protein binding
GO:0005540 hyaluronic acid binding
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019899 enzyme binding
GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity
GO:0030971 receptor tyrosine kinase binding
GO:0033906 hyaluronoglucuronidase activity
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0002244 hematopoietic progenitor cell differentiation
GO:0005975 carbohydrate metabolic process
GO:0006027 glycosaminoglycan catabolic process
GO:0008152 metabolic process
GO:0009615 response to virus
GO:0010259 multicellular organismal aging
GO:0010764 negative regulation of fibroblast migration
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019087 transformation of host cell by virus
GO:0030214 hyaluronan catabolic process
GO:0030308 negative regulation of cell growth
GO:0035810 positive regulation of urine volume
GO:0042117 monocyte activation
GO:0042307 positive regulation of protein import into nucleus
GO:0043407 negative regulation of MAP kinase activity
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046677 response to antibiotic
GO:0046718 viral entry into host cell
GO:0048705 skeletal system morphogenesis
GO:0050729 positive regulation of inflammatory response
GO:0051216 cartilage development
GO:0051607 defense response to virus
GO:0051898 negative regulation of protein kinase B signaling
GO:0060586 multicellular organismal iron ion homeostasis
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0070295 renal water absorption
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071493 cellular response to UV-B
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000484 positive regulation of interleukin-8 secretion
GO:2000778 positive regulation of interleukin-6 secretion
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0009986 cell surface
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016324 apical plasma membrane
GO:0030139 endocytic vesicle
GO:0031225 anchored component of membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0045121 membrane raft
GO:0046658 anchored component of plasma membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR017853 Glycoside hydrolase, superfamily
IPR018155 Hyaluronidase
PFAM PF01630
PRINTS PR00846
PIRSF PIRSF038193
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8SQG8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281838
UniGene Bt.29683
RefSeq NP_776772
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF411973 BC102042 BT021810 BT026155
GenPept AAI02043 AAL78385 AAX46657 ABG66994

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca