Version 5.4
Bos taurus Protein: PAIP2
Summary
InnateDB Protein IDBP-698773.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAIP2
Protein Name Polyadenylate-binding protein-interacting protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010815
InnateDB Gene IDBG-646011 (PAIP2)
Protein Structure
UniProt Annotation
Function Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0030371 translation repressor activity
Biological Process
GO:0006417 regulation of translation
GO:0007283 spermatogenesis
GO:0007613 memory
GO:0045947 negative regulation of translational initiation
GO:1900271 regulation of long-term synaptic potentiation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR009818 Ataxin-2, C-terminal
PFAM PF07145
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZC67
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 536619
UniGene Bt.52795
RefSeq NP_001029808
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102885
GenPept AAI02886

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca