InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RNASE1

Summary

InnateDB Protein

IDBP-698814.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNASE1

Protein Name

Ribonuclease pancreatic

Synonyms

RNS1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011586

InnateDB Gene

IDBG-646043 (RNASE1)

Protein Structure

UniProt Annotation

Function

Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA. {ECO:0000269PubMed:7479688}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0004522	pancreatic ribonuclease activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters

Biological Process

GO:0008152	metabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR001427 Pancreatic ribonuclease
IPR023412 Ribonuclease A-domain

PFAM

PF00074

PRINTS

PR00794

PIRSF

SMART

SM00092

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P61823

PhosphoSite

PhosphoSite-

TrEMBL

W0UVI3

UniProt Splice Variant

Entrez Gene

282340

UniGene

Bt.4630

RefSeq

NP_001014408

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC149529 BC149636 HG329012 S80747 S81740 X07283

GenPept

AAB35594 AAB36134 AAI49530 AAI49637 CAA30263 CDG32088