InnateDB Protein
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IDBP-699013.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GRPEL2
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Protein Name
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GrpE protein homolog 2, mitochondrial
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000026575
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InnateDB Gene
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IDBG-646231 (GRPEL2)
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Protein Structure
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Function |
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion matrix {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000740
GrpE nucleotide exchange factor
IPR009012
GrpE nucleotide exchange factor, head
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PFAM |
PF01025
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PRINTS |
PR00773
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q0P5N5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
514599
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UniGene |
Bt.68425
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RefSeq |
NP_001069142
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC119818
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GenPept |
AAI19819
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