InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LTF

Summary

InnateDB Protein

IDBP-699029.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTF

Protein Name

LactotransferrinLactoferricin-B

Synonyms

Lf;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001704

InnateDB Gene

IDBG-646243 (LTF)

Protein Structure

UniProt Annotation

Function

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity. Antimicrobial properties may include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. The most effective inhibitory activity is seen against E.coli and P.aeruginosa. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Interferes with the lipopolysaccharide (LPS)- stimulated TLR4 signaling, but cannot directly stimulate the TLR4 signaling pathway and subsequent NF-kappa-B activation.Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.

Subcellular Localization

Secreted. Cytoplasmic granule {ECO:0000250}. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008199	ferric iron binding
GO:0008201	heparin binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity
GO:0043539	protein serine/threonine kinase activator activity
GO:0046872	metal ion binding

Biological Process

GO:0001503	ossification
GO:0001817	regulation of cytokine production
GO:0001895	retina homeostasis
GO:0002227	innate immune response in mucosa
GO:0002376	immune system process
GO:0006508	proteolysis
GO:0006810	transport
GO:0006811	ion transport
GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0019731	antibacterial humoral response
GO:0019732	antifungal humoral response
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032680	regulation of tumor necrosis factor production
GO:0033690	positive regulation of osteoblast proliferation
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0042742	defense response to bacterium
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045669	positive regulation of osteoblast differentiation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0055072	iron ion homeostasis
GO:0060349	bone morphogenesis
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:1900159	positive regulation of bone mineralization involved in bone maturation
GO:1900229	negative regulation of single-species biofilm formation in or on host organism
GO:1902732	positive regulation of chondrocyte proliferation
GO:2000308	negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2001205	negative regulation of osteoclast development

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030141	secretory granule
GO:0042581	specific granule
GO:0070062	extracellular vesicular exosome