InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PPARG

Summary

InnateDB Protein

IDBP-699195.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARG

Protein Name

Peroxisome proliferator-activated receptor gamma

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001760

InnateDB Gene

IDBG-646391 (PPARG)

Protein Structure

UniProt Annotation

Function

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}. Cytoplasm {ECO:0000250}. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest expression in adipose tissue. Lower in spleen and lung. Also detected in ovary, mammary gland and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 106 interaction(s) predicted by orthology.

Predicted by orthology
Total	106 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008270	zinc ion binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030855	epithelial cell differentiation
GO:0032526	response to retinoic acid
GO:0043401	steroid hormone mediated signaling pathway
GO:0045165	cell fate commitment
GO:0045598	regulation of fat cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050872	white fat cell differentiation
GO:0060850	regulation of transcription involved in cell fate commitment

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003074 Peroxisome proliferator-activated receptor
IPR003077 Peroxisome proliferator-activated receptor, gamma
IPR008946 Nuclear hormone receptor, ligand-binding
IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal

PFAM

PF00104
PF00105
PF12577

PRINTS

PR00047
PR00398
PR01288
PR01291

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O18971

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281993

UniGene

RefSeq

XP_005223180

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY179866 BC116098 Y12419 Y12420

GenPept

AAI16099 AAN75018 CAA73032 CAA73033