Version 5.4
Bos taurus Protein: PPARG
Summary
InnateDB Protein IDBP-699197.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPARG
Protein Name Peroxisome proliferator-activated receptor gamma
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000041555
InnateDB Gene IDBG-646391 (PPARG)
Protein Structure
UniProt Annotation
Function Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}. Cytoplasm {ECO:0000250}. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Highest expression in adipose tissue. Lower in spleen and lung. Also detected in ovary, mammary gland and small intestine.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 106 interaction(s) predicted by orthology.
Predicted by orthology
Total 106 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001012 RNA polymerase II regulatory region DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0033613 activating transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0046965 retinoid X receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001890 placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell proliferation
GO:0010871 negative regulation of receptor biosynthetic process
GO:0010887 negative regulation of cholesterol storage
GO:0010891 negative regulation of sequestering of triglyceride
GO:0015909 long-chain fatty acid transport
GO:0030224 monocyte differentiation
GO:0030855 epithelial cell differentiation
GO:0032526 response to retinoic acid
GO:0032869 cellular response to insulin stimulus
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0042593 glucose homeostasis
GO:0042953 lipoprotein transport
GO:0043401 steroid hormone mediated signaling pathway
GO:0045165 cell fate commitment
GO:0045444 fat cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045713 low-density lipoprotein particle receptor biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050872 white fat cell differentiation
GO:0050873 brown fat cell differentiation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0055098 response to low-density lipoprotein particle stimulus
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060850 regulation of transcription involved in cell fate commitment
GO:0071285 cellular response to lithium ion
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003074 Peroxisome proliferator-activated receptor
IPR003077 Peroxisome proliferator-activated receptor, gamma
IPR008946 Nuclear hormone receptor, ligand-binding
IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal
PFAM PF00104
PF00105
PF12577
PRINTS PR00047
PR00398
PR01288
PR01291
PIRSF
SMART SM00430
SM00399
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O18971
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281993
UniGene
RefSeq NP_851367
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY179866 BC116098 Y12419 Y12420
GenPept AAI16099 AAN75018 CAA73032 CAA73033

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca