InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DNAAF2

Summary

InnateDB Protein

IDBP-699203.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAAF2

Protein Name

Protein kintoun

Synonyms

C10H14orf104; C14orf104; KTU;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000042390

InnateDB Gene

IDBG-646398 (DNAAF2)

Protein Structure

UniProt Annotation

Function

Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0010033	response to organic substance
GO:0032526	response to retinoic acid
GO:0060285	cilium-dependent cell motility
GO:0070286	axonemal dynein complex assembly
GO:0071973	bacterial-type flagellum-dependent cell motility

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR012981 PIH1 family

PFAM

PF08190

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VC73

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

534465

UniGene

Bt.50656

RefSeq

NP_001069492

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AAFC03057991 AAFC03057994 BC120319

GenPept

AAI20320