InnateDB Protein
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IDBP-699235.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLU7
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Protein Name
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Pre-mRNA-splicing factor SLU7
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000011131
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InnateDB Gene
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IDBG-646430 (SLU7)
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Protein Structure
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Function |
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
18 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001878
Zinc finger, CCHC-type
IPR021715
Pre-mRNA splicing Prp18-interacting factor
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PFAM |
PF00098
PF11708
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PRINTS |
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PIRSF |
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SMART |
SM00343
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TIGRFAMs |
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Modification |
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SwissProt |
Q3ZBE5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
512318
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UniGene |
Bt.105667
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RefSeq |
NP_001160089
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC103394
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GenPept |
AAI03395
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