Version 5.4
Bos taurus Protein: RARS
Summary
InnateDB Protein IDBP-699280.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RARS
Protein Name Arginyl-tRNA synthetase, cytoplasmic
Synonyms ArgRS;
Species Bos taurus
Ensembl Protein ENSBTAP00000019475
InnateDB Gene IDBG-646471 (RARS)
Protein Structure
UniProt Annotation
Function Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (By similarity). {ECO:0000250UniProtKB:P54136}.
Subcellular Localization Cytoplasm {ECO:0000250UniProtKB:P54136}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004814 arginine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006420 arginyl-tRNA aminoacylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001278 Arginine-tRNA ligase
IPR005148 Arginyl tRNA synthetase N-terminal domain
IPR008909 DALR anticodon binding
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
PFAM PF00750
PF03485
PF05746
PRINTS PR01038
PIRSF
SMART SM01016
SM00836
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7YW98
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506305
UniGene Bt.22038
RefSeq NP_001098808
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134468
GenPept AAI34469

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca