InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RORA

Summary

InnateDB Protein

IDBP-699388.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RORA

Protein Name

RAR-related orphan receptor A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021144

InnateDB Gene

IDBG-646570 (RORA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001222	transcription corepressor binding
GO:0001223	transcription coactivator binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008142	oxysterol binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0098531	direct ligand regulated sequence-specific DNA binding transcription factor activity

Biological Process

GO:0001525	angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006805	xenobiotic metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0008589	regulation of smoothened signaling pathway
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010906	regulation of glucose metabolic process
GO:0019218	regulation of steroid metabolic process
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021930	cerebellar granule cell precursor proliferation
GO:0030522	intracellular receptor signaling pathway
GO:0032922	circadian regulation of gene expression
GO:0036315	cellular response to sterol
GO:0042692	muscle cell differentiation
GO:0042752	regulation of circadian rhythm
GO:0042753	positive regulation of circadian rhythm
GO:0043030	regulation of macrophage activation
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401	steroid hormone mediated signaling pathway
GO:0045599	negative regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046068	cGMP metabolic process
GO:0050728	negative regulation of inflammatory response
GO:0060850	regulation of transcription involved in cell fate commitment
GO:0070328	triglyceride homeostasis
GO:0071456	cellular response to hypoxia
GO:0072539	T-helper 17 cell differentiation
GO:2000188	regulation of cholesterol homeostasis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR003079 Nuclear receptor ROR
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR00546
PR01293

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt