InnateDB Protein
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IDBP-699469.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARPP19
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Protein Name
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cAMP-regulated phosphoprotein 19
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Synonyms
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ARPP-16; ARPP-19;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000014642
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InnateDB Gene
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IDBG-646646 (ARPP19)
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Protein Structure
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Function |
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform ARPP-19 is found in all brain regions and also present in non-neuronal tissues. Isoform ARPP-16 is enriched in the caudate nucleus, found in low levels in cerebral cortex.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004864
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protein phosphatase inhibitor activity
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GO:0008601
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protein phosphatase type 2A regulator activity
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GO:0019212
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phosphatase inhibitor activity
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GO:0051721
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protein phosphatase 2A binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006760
Endosulphine
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PFAM |
PF04667
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q28055
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
282658
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UniGene |
Bt.68471
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RefSeq |
NP_777130
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
M33617
M33618
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GenPept |
AAA30385
AAA30386
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