Version 5.4
Bos taurus Protein: BMP4
Summary
InnateDB Protein IDBP-699534.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMP4
Protein Name Bone morphogenetic protein 4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004992
InnateDB Gene IDBG-646706 (BMP4)
Protein Structure
UniProt Annotation
Function Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0042056 chemoattractant activity
GO:0070700 BMP receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000186 activation of MAPKK activity
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001707 mesoderm formation
GO:0001759 organ induction
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001944 vasculature development
GO:0001958 endochondral ossification
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062 chondrocyte differentiation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0003014 renal system process
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003139 secondary heart field specification
GO:0003323 type B pancreatic cell development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0007275 multicellular organismal development
GO:0007281 germ cell development
GO:0007500 mesodermal cell fate determination
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009791 post-embryonic development
GO:0009888 tissue development
GO:0009948 anterior/posterior axis specification
GO:0010159 specification of organ position
GO:0010453 regulation of cell fate commitment
GO:0010468 regulation of gene expression
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942 positive regulation of cell death
GO:0021537 telencephalon development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021978 telencephalon regionalization
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030900 forebrain development
GO:0032092 positive regulation of protein binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0034504 protein localization to nucleus
GO:0035116 embryonic hindlimb morphogenesis
GO:0035990 tendon cell differentiation
GO:0035993 deltoid tuberosity development
GO:0040007 growth
GO:0042326 negative regulation of phosphorylation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0043010 camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0045165 cell fate commitment
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045606 positive regulation of epidermal cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0045839 negative regulation of mitosis
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0048333 mesodermal cell differentiation
GO:0048392 intermediate mesodermal cell differentiation
GO:0048593 camera-type eye morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048663 neuron fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048745 smooth muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050918 positive chemotaxis
GO:0051145 smooth muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051216 cartilage development
GO:0055020 positive regulation of cardiac muscle fiber development
GO:0060113 inner ear receptor cell differentiation
GO:0060197 cloacal septation
GO:0060235 lens induction in camera-type eye
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060348 bone development
GO:0060363 cranial suture morphogenesis
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060425 lung morphogenesis
GO:0060429 epithelium development
GO:0060433 bronchus development
GO:0060438 trachea development
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060449 bud elongation involved in lung branching
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060503 bud dilation involved in lung branching
GO:0060512 prostate gland morphogenesis
GO:0060548 negative regulation of cell death
GO:0060592 mammary gland formation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0060686 negative regulation of prostatic bud formation
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060688 regulation of morphogenesis of a branching structure
GO:0061035 regulation of cartilage development
GO:0061036 positive regulation of cartilage development
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061149 BMP signaling pathway involved in ureter morphogenesis
GO:0061151 BMP signaling pathway involved in renal system segmentation
GO:0061155 pulmonary artery endothelial tube morphogenesis
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071893 BMP signaling pathway involved in nephric duct formation
GO:0072001 renal system development
GO:0072015 glomerular visceral epithelial cell development
GO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104 glomerular capillary formation
GO:0072125 negative regulation of glomerular mesangial cell proliferation
GO:0072138 mesenchymal cell proliferation involved in ureteric bud development
GO:0072161 mesenchymal cell differentiation involved in kidney development
GO:0072192 ureter epithelial cell differentiation
GO:0072193 ureter smooth muscle cell differentiation
GO:0072198 mesenchymal cell proliferation involved in ureter development
GO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205 metanephric collecting duct development
GO:0090184 positive regulation of kidney development
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194 negative regulation of glomerulus development
GO:2000005 negative regulation of metanephric S-shaped body morphogenesis
GO:2000007 negative regulation of metanephric comma-shaped body morphogenesis
GO:2000105 positive regulation of DNA-dependent DNA replication
GO:2000137 negative regulation of cell proliferation involved in heart morphogenesis
GO:2001012 mesenchymal cell differentiation involved in renal system development
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR029034 Cystine-knot cytokine
PFAM PF00688
PF00019
PRINTS
PIRSF
SMART SM00204
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KJH1
PhosphoSite PhosphoSite-
TrEMBL Q4VS18
UniProt Splice Variant
Entrez Gene 407216
UniGene Bt.28459
RefSeq NP_001039342
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB194773 AY642851 BC105344
GenPept AAI05345 AAV34168 BAE03196

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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