InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MTHFD1

Summary

InnateDB Protein

IDBP-699601.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTHFD1

Protein Name

C-1-tetrahydrofolate synthase, cytoplasmic

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012704

InnateDB Gene

IDBG-646769 (MTHFD1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004329	formate-tetrahydrofolate ligase activity
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524	ATP binding

Biological Process

GO:0006730	one-carbon metabolic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000559 Formate-tetrahydrofolate ligase, FTHFS
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01268
PF00763
PF02882

PRINTS

PR00085

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite