Version 5.4
Bos taurus Protein: ZFYVE26
Summary
InnateDB Protein IDBP-699634.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFYVE26
Protein Name Zinc finger FYVE domain-containing protein 26
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000040846
InnateDB Gene IDBG-646798 (ZFYVE26)
Protein Structure
UniProt Annotation
Function Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Midbody {ECO:0000250}. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0046872 metal ion binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000910 cytokinesis
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0030496 midbody
Protein Structure and Domains
PDB ID
InterPro IPR000306 FYVE zinc finger
IPR009061 DNA binding domain, putative
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF01363
PRINTS
PIRSF
SMART SM00064
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E1BLZ4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514402
UniGene
RefSeq NP_001192718
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03015524 AAFC03064315
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca