Version 5.4
Bos taurus Protein: H2AFX
Summary
InnateDB Protein IDBP-700251.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2AFX
Protein Name H2A histone family, member X
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000050955
InnateDB Gene IDBG-647424 (H2AFX)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 207 interaction(s) predicted by orthology.
Predicted by orthology
Total 207 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042393 histone binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006334 nucleosome assembly
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000790 nuclear chromatin
GO:0000794 condensed nuclear chromosome
GO:0001673 male germ cell nucleus
GO:0001741 XY body
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005657 replication fork
GO:0005694 chromosome
GO:0035861 site of double-strand break
Protein Structure and Domains
PDB ID
InterPro IPR002119 Histone H2A
IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS PR00620
PIRSF
SMART SM00414
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q2VT23
UniProt Splice Variant
Entrez Gene 531733
UniGene Bt.10510
RefSeq NP_001073248
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY835842 BC118370 DAAA02040492
GenPept AAI18371 AAX39431

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca