Version 5.4
Bos taurus Protein: PPAPDC2
Summary
InnateDB Protein IDBP-700277.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPAPDC2
Protein Name Presqualene diphosphate phosphatase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014674
InnateDB Gene IDBG-647455 (PPAPDC2)
Protein Structure
UniProt Annotation
Function Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
PFAM PF01569
PRINTS
PIRSF
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58DI5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 541021
UniGene Bt.28203
RefSeq NP_001019744
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC147999 BT021612
GenPept AAI48000 AAX46459

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca