InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CMLKR1

Summary

InnateDB Protein

IDBP-700675.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CMLKR1

Protein Name

Chemokine-like receptor 1

Synonyms

Cmklr-1; CMLKR1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000029488

InnateDB Gene

IDBG-647886 (CMLKR1)

Protein Structure

UniProt Annotation

Function

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed in several tissues including adipose, muscle, liver and brain. {ECO:0000269PubMed:20399065}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010759	positive regulation of macrophage chemotaxis
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032695	negative regulation of interleukin-12 production
GO:0045600	positive regulation of fat cell differentiation
GO:0050848	regulation of calcium-mediated signaling
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002234 Anaphylatoxin chemotactic receptor family
IPR002258 DEZ orphan receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00241
PR00237
PR01104
PR01126

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

B9VR26