InnateDB Protein
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IDBP-70076.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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OPA1
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Protein Name
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optic atrophy 1 (autosomal dominant)
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Synonyms
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largeG; MGM1; NPG; NTG;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000354681
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InnateDB Gene
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IDBG-70072 (OPA1)
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Protein Structure
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Function |
Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space.Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.
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Subcellular Localization |
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space.
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Disease Associations |
Optic atrophy 1 (OPA1) [MIM:165500]: A condition that features progressive visual loss in association with optic atrophy. Atrophy of the optic disk indicates a deficiency in the number of nerve fibers which arise in the retina and converge to form the optic disk, optic nerve, optic chiasm and optic tracts. OPA1 is characterized by an insidious onset of visual impairment in early childhood with moderate to severe loss of visual acuity, temporal optic disk pallor, color vision deficits, and centrocecal scotoma of variable density. {ECO:0000269PubMed:11017079, ECO:0000269PubMed:11017080, ECO:0000269PubMed:11440988, ECO:0000269PubMed:11440989, ECO:0000269PubMed:11810270, ECO:0000269PubMed:12036970, ECO:0000269PubMed:12566046, ECO:0000269PubMed:14961560, ECO:0000269PubMed:15948788, ECO:0000269PubMed:16513463, ECO:0000269PubMed:16617242, ECO:0000269PubMed:19319978, ECO:0000269PubMed:19325939, ECO:0000269PubMed:22382025}. Note=The disease is caused by mutations affecting the gene represented in this entry.Dominant optic atrophy plus syndrome (DOA+) [MIM:125250]: A neurologic disorder characterized most commonly by an insidious onset of visual loss and sensorineural hearing loss in childhood with variable presentation of other clinical manifestations including progressive external ophthalmoplegia, muscle cramps, hyperreflexia, and ataxia. There appears to be a wide range of intermediate phenotypes. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues. {ECO:0000269PubMed:11017079, ECO:0000269PubMed:11017080, ECO:0000269PubMed:11810270}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001401
Dynamin, GTPase domain
IPR022812
Dynamin superfamily
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00350
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PRINTS |
PR00195
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PIRSF |
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SMART |
SM00053
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TIGRFAMs |
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Modification |
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SwissProt |
O60313
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PhosphoSite |
PhosphoSite-O60313
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TrEMBL |
Q6PEK6
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UniProt Splice Variant |
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Entrez Gene |
4976
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UniGene |
Hs.743613
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RefSeq |
NP_570849
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HUGO |
HGNC:8140
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OMIM |
605290
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CCDS |
CCDS33917
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HPRD |
05596
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IMGT |
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EMBL |
AB011139
AC048351
AC106710
AF416919
AF416920
BC058013
BC075805
CH471052
HQ204906
HQ204907
HQ204908
HQ204910
HQ204911
HQ204912
HQ204913
HQ204914
HQ204917
HQ204918
HQ204920
HQ204921
HQ204922
HQ204923
HQ204924
HQ204925
HQ204926
HQ204927
HQ204929
HQ204930
HQ204932
HQ204933
HQ204934
HQ204935
HQ204936
HQ204938
HQ204939
HQ204940
HQ204941
HQ204942
HQ204943
HQ204944
HQ204945
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GenPept |
AAH58013
AAH75805
ADP90056
ADP90057
ADP90064
ADP90065
ADP90072
ADP90073
ADP90088
ADP90089
ADP90096
ADP90097
ADP90104
ADP90105
ADP90112
ADP90113
ADP90120
ADP90121
ADP90144
ADP90145
ADP90152
ADP90153
ADP90168
ADP90169
ADP90176
ADP90177
ADP90184
ADP90185
ADP90192
ADP90193
ADP90200
ADP90201
ADP90208
ADP90209
ADP90216
ADP90217
ADP90224
ADP90225
ADP90240
ADP90241
ADP90248
ADP90249
ADP90264
ADP90265
ADP90272
ADP90273
ADP90280
ADP90281
ADP90288
ADP90289
ADP90296
ADP90297
ADP90312
ADP90313
ADP90320
ADP90321
ADP90328
ADP90329
ADP90336
ADP90337
ADP90344
ADP90345
ADP90352
ADP90353
ADP90360
ADP90361
ADP90368
ADP90369
BAA25493
EAW78064
EAW78067
EAW78071
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