Version 5.4
Bos taurus Protein: FZD1
Summary
InnateDB Protein IDBP-700913.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FZD1
Protein Name frizzled-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002720
InnateDB Gene IDBG-648147 (FZD1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0001944 vasculature development
GO:0003149 membranous septum morphogenesis
GO:0003150 muscular septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0007166 cell surface receptor signaling pathway
GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0008406 gonad development
GO:0016055 Wnt signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030855 epithelial cell differentiation
GO:0035414 negative regulation of catenin import into nucleus
GO:0035425 autocrine signaling
GO:0042493 response to drug
GO:0044338 canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
GO:0044339 canonical Wnt receptor signaling pathway involved in osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048286 lung alveolus development
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060022 hard palate development
GO:0060070 canonical Wnt signaling pathway
GO:0060412 ventricular septum morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090179 planar cell polarity pathway involved in neural tube closure
Cellular Component
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032589 neuron projection membrane
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID
InterPro IPR000539 Frizzled protein
IPR017981 GPCR, family 2-like
IPR020067 Frizzled domain
PFAM PF01534
PF01392
PRINTS PR00489
PIRSF
SMART SM00063
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q68RG1
UniProt Splice Variant
Entrez Gene 445417
UniGene Bt.69087
RefSeq NP_001094518
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB257755 AY624568 BC151283 DAAA02009738
GenPept AAI51284 AAT95335 BAE93506

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca