InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SPRY2

Summary

InnateDB Protein

IDBP-701139.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPRY2

Protein Name

Protein sprouty homolog 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000043748

InnateDB Gene

IDBG-648383 (SPRY2)

Protein Structure

UniProt Annotation

Function

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0007275	multicellular organismal development
GO:0007605	sensory perception of sound
GO:0008285	negative regulation of cell proliferation
GO:0009966	regulation of signal transduction
GO:0010628	positive regulation of gene expression
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0030324	lung development
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034261	negative regulation of Ras GTPase activity
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042472	inner ear morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043407	negative regulation of MAP kinase activity
GO:0045165	cell fate commitment
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048754	branching morphogenesis of an epithelial tube
GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
GO:0051897	positive regulation of protein kinase B signaling
GO:0060425	lung morphogenesis
GO:0060437	lung growth
GO:0060449	bud elongation involved in lung branching
GO:0060541	respiratory system development
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR007875 Sprouty

PFAM

PF05210

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08E39

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

539090

UniGene

Bt.28178

RefSeq

NP_001069615

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123435

GenPept

AAI23436