InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FBXL14

Summary

InnateDB Protein

IDBP-701168.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXL14

Protein Name

F-box/LRR-repeat protein 14

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010237

InnateDB Gene

IDBG-648420 (FBXL14)

Protein Structure

UniProt Annotation

Function

Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0042787

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

InterPro

IPR001611 Leucine-rich repeat
IPR001810 F-box domain
IPR006553 Leucine-rich repeat, cysteine-containing subtype
IPR013101 Leucine-rich repeat 2

PFAM

PF00560
PF13504
PF13855
PF00646
PF12937
PF13013
PF07723

PRINTS

PIRSF

SMART

SM00256
SM00367

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q17R01

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

531211

UniGene

Bt.12202

RefSeq

NP_001069415

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC118093

GenPept

AAI18094