InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPAT

Summary

InnateDB Protein

IDBP-70181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPAT

Protein Name

nuclear protein, ataxia-telangiectasia locus

Synonyms

E14; E14/NPAT; p220;

Species

Homo sapiens

Ensembl Protein

ENSP00000278612

InnateDB Gene

IDBG-70179 (NPAT)

Protein Structure

UniProt Annotation

Function

Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269PubMed:10995386, ECO:0000269PubMed:10995387, ECO:0000269PubMed:12665581, ECO:0000269PubMed:12724424, ECO:0000269PubMed:14585971, ECO:0000269PubMed:14612403, ECO:0000269PubMed:15555599, ECO:0000269PubMed:15988025, ECO:0000269PubMed:16131487, ECO:0000269PubMed:17163457, ECO:0000269PubMed:17826007, ECO:0000269PubMed:17967892, ECO:0000269PubMed:17974976, ECO:0000269PubMed:9472014}.

Subcellular Localization

Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:8743993, ECO:0000269PubMed:8923007}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	20 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0010468	regulation of gene expression
GO:0045893	positive regulation of transcription, DNA-templated