InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OIP5

Summary

InnateDB Protein

IDBP-7022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OIP5

Protein Name

Opa interacting protein 5

Synonyms

5730547N13Rik; CT86; hMIS18beta; LINT-25; MIS18B; MIS18beta;

Species

Homo sapiens

Ensembl Protein

ENSP00000220514

InnateDB Gene

IDBG-7020 (OIP5)

Protein Structure

UniProt Annotation

Function

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269PubMed:17199038}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17199038}. Chromosome {ECO:0000269PubMed:17199038}. Chromosome, centromere {ECO:0000269PubMed:17199038}. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006334	nucleosome assembly
GO:0007067	mitotic nuclear division
GO:0007154	cell communication
GO:0034080	centromere-specific nucleosome assembly

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0010369	chromocenter
GO:0015030	Cajal body