InnateDB Protein
|
IDBP-705282.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Lzts2
|
Protein Name
|
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000136405
|
InnateDB Gene
|
IDBG-170440 (Lzts2)
|
Protein Structure
|
|
Function |
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255HAMAP-Rule:MF_03026}.
|
Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03026}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255HAMAP-Rule:MF_03026, ECO:0000269PubMed:18490357}. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. {ECO:0000255HAMAP-Rule:MF_03026}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
8
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
18 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2385095
|
InterPro |
IPR009053
Prefoldin
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q91YU6
|
PhosphoSite |
PhosphoSite-Q91YU6
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
226154
|
UniGene |
Mm.28204
|
RefSeq |
NP_001123998
|
MGI ID |
|
MGI Symbol |
Lzts2
|
OMIM |
|
CCDS |
CCDS29855
|
HPRD |
|
IMGT |
|
EMBL |
AC132957
AK129446
BC014695
BC092263
|
GenPept |
AAH14695
AAH92263
BAC98256
|
|
|