Version 5.4
Homo sapiens Protein: PGS1
Summary
InnateDB Protein IDBP-70721.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGS1
Protein Name phosphatidylglycerophosphate synthase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000262764
InnateDB Gene IDBG-70715 (PGS1)
Protein Structure
UniProt Annotation
Function Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006655 phosphatidylglycerol biosynthetic process
GO:0008152 metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0032049 cardiolipin biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046339 diacylglycerol metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro IPR001736 Phospholipase D/Transphosphatidylase
IPR016270 Phospholipase D, phosphatidylserine synthase type
PFAM PF00614
PRINTS
PIRSF PIRSF000850
SMART SM00155
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32NB8
PhosphoSite PhosphoSite-Q32NB8
TrEMBL A0A024R8V5
UniProt Splice Variant
Entrez Gene 9489
UniGene Hs.666406
RefSeq NP_077733
HUGO HGNC:30029
OMIM 614942
CCDS CCDS42391
HPRD 17841
IMGT
EMBL AK024529 AK316147 AL359590 BC008903 BC015570 BC025951 BC035662 BC108732 CH471099 CR749720
GenPept AAH08903 AAH15570 AAH25951 AAH35662 AAI08733 BAB14921 BAH14518 CAB94876 CAH18487 EAW89524 EAW89525

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca