InnateDB Protein
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IDBP-70780.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZFAND5
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Protein Name
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zinc finger, AN1-type domain 5
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Synonyms
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ZA20D2; ZFAND5A; ZNF216;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000366161
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InnateDB Gene
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IDBG-70778 (ZFAND5)
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Protein Structure
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Function |
Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269PubMed:14754897}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level). {ECO:0000269PubMed:14754897, ECO:0000269PubMed:9758550}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000058
Zinc finger, AN1-type
IPR002653
Zinc finger, A20-type
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PFAM |
PF01428
PF01754
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PRINTS |
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PIRSF |
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SMART |
SM00154
SM00259
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TIGRFAMs |
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Modification |
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SwissProt |
O76080
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PhosphoSite |
PhosphoSite-O76080
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TrEMBL |
A0A024R219
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UniProt Splice Variant |
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Entrez Gene |
7763
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UniGene |
Hs.653315
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RefSeq |
NP_001095890
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HUGO |
HGNC:13008
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OMIM |
604761
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CCDS |
CCDS6642
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HPRD |
05302
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IMGT |
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EMBL |
AF062072
AF062346
AF062347
AK290849
AL135924
BC011018
BC027707
BC073131
CH471089
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GenPept |
AAC42601
AAC42602
AAC61801
AAH11018
AAH27707
AAH73131
BAF83538
CAD13440
EAW62533
EAW62536
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