Version 5.4
| Homo sapiens Protein: LIPI | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-708.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | LIPI | ||||||||
| Protein Name | lipase, member I | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000343331 | ||||||||
| InnateDB Gene | IDBG-706 (LIPI) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269PubMed:12963729}. | ||||||||
| Subcellular Localization | Isoform 1: Membrane. Secreted. Note=May associate with lipid draft.Isoform 2: Membrane. Note=May associate with lipid draft. | ||||||||
| Disease Associations | Hypertriglyceridemia, familial (FHTR) [MIM:145750]: A common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||||||||
| Tissue Specificity | Expressed in testis. Expressed exclusively at the connecting piece of the sperm. {ECO:0000269PubMed:12719377, ECO:0000269PubMed:12963729}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000734
Lipase IPR013818 Lipase, N-terminal IPR016272 Lipoprotein lipase, LIPH IPR029058 Alpha/Beta hydrolase fold |
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| PFAM |
PF00151
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| PRINTS |
PR00821
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| PIRSF |
PIRSF000865
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| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q6XZB0 | ||||||||
| PhosphoSite | PhosphoSite-Q6XZB0 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 149998 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_945347 | ||||||||
| HUGO | HGNC:18821 | ||||||||
| OMIM | 609252 | ||||||||
| CCDS | CCDS13564 | ||||||||
| HPRD | 14193 | ||||||||
| IMGT | |||||||||
| EMBL | AF130358 AL078615 AP001347 AY197607 JN387910 JN387911 JN387912 JN387913 JN387914 JN387915 JN387916 | ||||||||
| GenPept | AAP37476 AEL12688 AEL12689 AEL12690 AEL12691 AEL12692 AEL12693 AEL12694 | ||||||||