Version 5.4
Homo sapiens Protein: FIZ1
Summary
InnateDB Protein IDBP-70899.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FIZ1
Protein Name FLT3-interacting zinc finger 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000221665
InnateDB Gene IDBG-70860 (FIZ1)
Protein Structure
UniProt Annotation
Function May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12566383}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030971 receptor tyrosine kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96SL8
PhosphoSite PhosphoSite-Q96SL8
TrEMBL K7EQX6
UniProt Splice Variant
Entrez Gene 84922
UniGene Hs.625842
RefSeq NP_116225
HUGO HGNC:25917
OMIM 609133
CCDS CCDS12928
HPRD 07870
IMGT
EMBL AC008735 AK027674 AK160385 BC132777 BC136512 CH471135
GenPept AAI32778 AAI36513 BAB55286 BAD18728 EAW72392

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca