InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCM6

Summary

InnateDB Protein

IDBP-70954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM6

Protein Name

minichromosome maintenance complex component 6

Synonyms

MCG40308; Mis5; P105MCM;

Species

Homo sapiens

Ensembl Protein

ENSP00000264156

InnateDB Gene

IDBG-70952 (MCM6)

Protein Structure

UniProt Annotation

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. {ECO:0000269PubMed:9305914}.

Subcellular Localization

Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 113 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	113 [view]
Protein-Protein	108 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003697	single-stranded DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0042802	identical protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0042555	MCM complex

Protein Structure and Domains

PDB ID

InterPro

IPR000523 Magnesium chelatase, ChlI subunit
IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
IPR008049 DNA replication licensing factor Mcm6
IPR012340 Nucleic acid-binding, OB-fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01078
PF00493

PRINTS

PR01657
PR01662

PIRSF

SMART

SM00350

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt