InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: U2AF2

Summary

InnateDB Protein

IDBP-71023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

U2AF2

Protein Name

U2 small nuclear RNA auxiliary factor 2

Synonyms

U2AF65;

Species

Homo sapiens

Ensembl Protein

ENSP00000307863

InnateDB Gene

IDBG-71019 (U2AF2)

Protein Structure

UniProt Annotation

Function

Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269PubMed:15009664, ECO:0000269PubMed:19470458, ECO:0000269PubMed:19574390}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 183 experimentally validated interaction(s) in this database.

Experimentally validated
Total	183 [view]
Protein-Protein	182 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0048025	negative regulation of mRNA splicing, via spliceosome