InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASIP

Summary

InnateDB Protein

IDBP-710300.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASIP

Protein Name

Synonyms

AGSW; AGTI; AGTIL; ASP; SHEP9;

Species

Homo sapiens

Ensembl Protein

ENSP00000454804

InnateDB Gene

IDBG-68022 (ASIP)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0031779	melanocortin receptor binding
GO:0031781	type 3 melanocortin receptor binding
GO:0031782	type 4 melanocortin receptor binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008343	adult feeding behavior
GO:0009755	hormone-mediated signaling pathway
GO:0032402	melanosome transport
GO:0032438	melanosome organization
GO:0040030	regulation of molecular function, epigenetic
GO:0042438	melanin biosynthetic process
GO:0043473	pigmentation
GO:0071514	genetic imprinting