Version 5.4
Homo sapiens Protein: AMZ1
Summary
InnateDB Protein IDBP-7119.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMZ1
Protein Name archaelysin family metallopeptidase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000308149
InnateDB Gene IDBG-7117 (AMZ1)
Protein Structure
UniProt Annotation
Function Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. {ECO:0000269PubMed:15972818}.
Subcellular Localization
Disease Associations
Tissue Specificity Predominantly expressed in heart and liver. Also expressed at lower level in kidney, pancreas and testis. Expressed in fetal tissues such as kidney, liver, lung and brain. {ECO:0000269PubMed:15972818}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR012962 Peptidase M54, archaemetzincin
PFAM PF07998
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q400G9
PhosphoSite PhosphoSite-Q400G9
TrEMBL B4DIY9
UniProt Splice Variant
Entrez Gene 155185
UniGene Hs.436046
RefSeq NP_597720
HUGO HGNC:22231
OMIM 615168
CCDS CCDS34589
HPRD 17232
IMGT
EMBL AB075830 AC006028 AJ635357 AK092107 AK289723 AK295842 BC146753 CH236953 CH471144
GenPept AAI46754 BAB85536 BAF82412 BAG52482 BAG58651 CAG25749 EAL23959 EAW87269

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca