InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLRP4

Summary

InnateDB Protein

IDBP-71191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRP4

Protein Name

NLR family, pyrin domain containing 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000301295

InnateDB Gene

IDBG-71189 (NLRP4)

Protein Structure

UniProt Annotation

Function

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways. {ECO:0000269PubMed:12093792, ECO:0000269PubMed:22388039}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding

Biological Process

GO:0006954	inflammatory response
GO:0032479	regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR004020 DAPIN domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02758

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96MN2