InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aspn

Summary

InnateDB Protein

IDBP-713553.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aspn

Protein Name

Synonyms

4631401G09Rik; AA986886; Plap1; Slrr1c;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136728

InnateDB Gene

IDBG-151082 (Aspn)

Protein Structure

UniProt Annotation

Function

Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins. Inhibits the interaction between TGFB1 and TGF-beta receptor type II in the presence of heparin/heparan sulfate in vitro. {ECO:0000250, ECO:0000269PubMed:17522060, ECO:0000269PubMed:17827158, ECO:0000269PubMed:18407830, ECO:0000269PubMed:20052601}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Higher expression in heart, also detected in kidney, stomach, testes, and skin but only weakly in lung, skeletal muscle, small intestine, and thymus. Expressed specifically and predominantly in the periodontal ligament (PDL). During tooth development, strong expression is seen in the dental follicle, which is the progenitor tissue that forms cementum, alveolar bone, and the PDL. Expressed in the perichondria of the maxilla, mandible, vertebrae, and long bones. Predominantly expressed in the perichondrium/periosteum of long bones (at protein level). {ECO:0000269PubMed:17522060, ECO:0000269PubMed:17804408}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005518	collagen binding

Biological Process

GO:0030282	bone mineralization
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0070171	negative regulation of tooth mineralization

Cellular Component

GO:0005578

proteinaceous extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1913945

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan

PFAM

PF01462
PF00560
PF13504
PF13855

PRINTS

PIRSF

PIRSF002490

SMART

SM00013
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt