InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prox1

Summary

InnateDB Protein

IDBP-713715.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prox1

Protein Name

Synonyms

A230003G05Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135066

InnateDB Gene

IDBG-208536 (Prox1)

Protein Structure

UniProt Annotation

Function

May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the young neurons of the subventricular region of the CNS, developing eye lens and pancreas. It is also found in the developing liver, heart and skeletal muscle. In the eye, expressed in the lens and retina at postnatal day 10. In the retina, localized to the inner nuclear layer. In the lens, localized to epithelial and fiber cells. {ECO:0000269PubMed:7908825, ECO:0000269PubMed:9703987}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0016922	ligand-dependent nuclear receptor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0050692	DBD domain binding
GO:0050693	LBD domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001709	cell fate determination
GO:0001822	kidney development
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001945	lymph vessel development
GO:0001946	lymphangiogenesis
GO:0002089	lens morphogenesis in camera-type eye
GO:0002194	hepatocyte cell migration
GO:0006366	transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0010595	positive regulation of endothelial cell migration
GO:0021542	dentate gyrus development
GO:0021707	cerebellar granule cell differentiation
GO:0030240	skeletal muscle thin filament assembly
GO:0030324	lung development
GO:0031016	pancreas development
GO:0031667	response to nutrient levels
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045071	negative regulation of viral genome replication
GO:0045446	endothelial cell differentiation
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045787	positive regulation of cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046619	optic placode formation involved in camera-type eye formation
GO:0048839	inner ear development
GO:0048845	venous blood vessel morphogenesis
GO:0055005	ventricular cardiac myofibril assembly
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:0060214	endocardium formation
GO:0060298	positive regulation of sarcomere organization
GO:0060412	ventricular septum morphogenesis
GO:0060414	aorta smooth muscle tissue morphogenesis
GO:0060421	positive regulation of heart growth
GO:0060836	lymphatic endothelial cell differentiation
GO:0060849	regulation of transcription involved in lymphatic endothelial cell fate commitment
GO:0070309	lens fiber cell morphogenesis
GO:0070365	hepatocyte differentiation
GO:0070858	negative regulation of bile acid biosynthetic process
GO:0072574	hepatocyte proliferation
GO:0097150	neuronal stem cell maintenance
GO:1901978	positive regulation of cell cycle checkpoint
GO:2000179	positive regulation of neural precursor cell proliferation
GO:2000979	positive regulation of forebrain neuron differentiation