InnateDB Protein
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IDBP-7142.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PINX1
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Protein Name
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PIN2/TERF1 interacting, telomerase inhibitor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000318966
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InnateDB Gene
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IDBG-404872 (PINX1)
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Protein Structure
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Function |
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269PubMed:15381700, ECO:0000269PubMed:17198684, ECO:0000269PubMed:19117989, ECO:0000269PubMed:19265708, ECO:0000269PubMed:19393617, ECO:0000269PubMed:19553660}.
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Subcellular Localization |
Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
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Disease Associations |
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Tissue Specificity |
Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
33
[view]
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Protein-Protein |
32
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000467
G-patch domain
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PFAM |
PF01585
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PRINTS |
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PIRSF |
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SMART |
SM00443
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TIGRFAMs |
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Modification |
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SwissProt |
Q96BK5
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PhosphoSite |
PhosphoSite-Q96BK5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
54984
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UniGene |
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RefSeq |
NP_060354
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HUGO |
HGNC:30046
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OMIM |
606505
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CCDS |
CCDS47801
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HPRD |
05934
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IMGT |
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EMBL |
AF205718
AF418553
AJ344104
AK000572
AK313715
AY029161
AY238941
AY523566
BC015479
BC093762
CH471157
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GenPept |
AAG18009
AAH15479
AAH93762
AAK31790
AAN31333
AAP37006
AAS19507
BAA91263
BAG36458
CAC51436
EAW65596
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