Version 5.4
Mus musculus Protein: Peg10
Summary
InnateDB Protein IDBP-714889.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Peg10
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000134963
InnateDB Gene IDBG-605798 (Peg10)
Protein Structure
UniProt Annotation
Function May have a role in cell growth promotion, apoptotic resistance and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1 (By similarity). Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter. {ECO:0000250, ECO:0000269PubMed:17707377}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells. Colocalized with ALK1 (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain and testis. Expressed during the early process of adipocyte differentiation. Expressed weakly in mammary gland but strongly in breast carcinomas of a c- MCY-driven transgenic model. {ECO:0000269PubMed:11574691, ECO:0000269PubMed:16423995, ECO:0000269PubMed:17707377}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0008270 zinc ion binding
Biological Process
GO:0001890 placenta development
GO:0006915 apoptotic process
GO:0030154 cell differentiation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2157785
InterPro IPR001878 Zinc finger, CCHC-type
IPR005162 Retrotransposon gag domain
PFAM PF00098
PF03732
PRINTS
PIRSF
SMART SM00343
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TN75
PhosphoSite PhosphoSite-Q7TN75
TrEMBL H3BL51
UniProt Splice Variant
Entrez Gene 170676
UniGene Mm.471407
RefSeq NP_001035701
MGI ID
MGI Symbol Peg10
OMIM
CCDS CCDS57407
HPRD
IMGT
EMBL AB091827 AC084315 AF302691
GenPept AAG39979 BAC77244

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca