InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgef2

Summary

InnateDB Protein

IDBP-716587.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgef2

Protein Name

Synonyms

AA408978; GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40; mKIAA0651; P40;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135428

InnateDB Gene

IDBG-161396 (Arhgef2)

Protein Structure

UniProt Annotation

Function

Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell junction, tight junction {ECO:0000269PubMed:12604587}. Golgi apparatus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization. Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (By similarity). Associated with apical intercellular junctions in the trophectoderm of the blastocyst. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous, with the exception of liver tissue. Levels are high in hemopoietic tissues (thymus, spleen, bone marrow) as well as in kidney and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0017048	Rho GTPase binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000902	cell morphogenesis
GO:0007015	actin filament organization
GO:0007026	negative regulation of microtubule depolymerization
GO:0007067	mitotic nuclear division
GO:0032314	regulation of Rac GTPase activity
GO:0032319	regulation of Rho GTPase activity
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768	negative regulation of neurogenesis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0071225	cellular response to muramyl dipeptide

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005819	spindle
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005923	tight junction
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0031982	vesicle
GO:0032587	ruffle membrane
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0043234	protein complex