InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp34

Summary

InnateDB Protein

IDBP-716886.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp34

Protein Name

Synonyms

A530081C03Rik; Murr2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137430

InnateDB Gene

IDBG-154559 (Usp34)

Protein Structure

UniProt Annotation

Function

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005488	binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016055	Wnt signaling pathway
GO:0071108	protein K48-linked deubiquitination
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:109473

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR016024 Armadillo-type fold
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6ZQ93

PhosphoSite