Version 5.4
Mus musculus Protein: Arhgef2
Summary
InnateDB Protein IDBP-716893.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef2
Protein Name
Synonyms AA408978; GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40; mKIAA0651; P40;
Species Mus musculus
Ensembl Protein ENSMUSP00000135808
InnateDB Gene IDBG-161396 (Arhgef2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0000902 cell morphogenesis
GO:0007015 actin filament organization
GO:0007026 negative regulation of microtubule depolymerization
GO:0032314 regulation of Rac GTPase activity
GO:0032319 regulation of Rho GTPase activity
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071225 cellular response to muramyl dipeptide
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0031982 vesicle
GO:0032587 ruffle membrane
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
Protein Structure and Domains
PDB ID MGI:103264
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
PFAM PF00130
PRINTS
PIRSF
SMART SM00109
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H3BLJ1
UniProt Splice Variant
Entrez Gene 16800
UniGene Mm.474712
RefSeq
MGI ID
MGI Symbol Arhgef2
OMIM
CCDS
HPRD
IMGT
EMBL AC145168
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca